Animated Image of a Man Suffering from A Restless Leg Syndrome

Restless Leg Syndrome:
Symptoms, Treatment, and Risk Factors

by Jill Zwarensteyn, Expert Reviewed by Dr. Alex Dimitriu M.D.

Disclaimer – Nothing on this website is intended to be a substitute for professional medical advice, diagnosis, or treatment… Read More Here.

Sometimes it’s not our minds that like to do the racing at night but rather our legs. If this sounds familiar, then there’s a good chance you’re dealing with Restless Legs Syndrome – or RLS.


For those who experience RLS, this condition may result in little or inconsistent sleep, which can be particularly stressful for folks who lead busy lives and rely on quality rest to get through the day. 


From what causes it to whether it’s a sign of a more severe health issue, we’ll answer all your questions about RLS.

Section 1

What is Restless Legs Syndrome?

Section 2

Risk Factors for Restless Legs Syndrome

Section 3

Is RLS Associated with Other Conditions?

Section 4

How to Stop Restless Legs

Section 5

Does RLS lead to Parkinson’s Disease?

Section 1

What is Restless Legs Syndrome?

Section 2

Risk Factors for Restless Legs Syndrome

Section 3

Is RLS Associated with Other Conditions?

Section 4

How to Stop Restless Legs

Section 5

Does RLS lead to Parkinson’s Disease?

Section 1

What is Restless Legs Syndrome?

Restless Legs Syndrome[1] is a condition in which a person feels an uncontrollable need to move their legs. In most cases, the desire to move is due to feeling uncomfortable sensations throughout the legs. Researchers believe RLS may result from an imbalance of dopamine, a chemical found in the brain that sends messages to regulate muscle movement.


RLS is also sometimes referred to as Willis-Ekbom disease. It is typically more pervasive at night and while someone is at rest, which is why it’s known to interrupt sleep.


About 5 percent of people experience Restless Legs Syndrome, however, it affects roughly 10 percent of people 65 and older[2].

What Does It Feel Like?

Illustration of a Lady with a Restless Leg Syndrom

People with Restless Legs Syndrome are usually prompted to move because they feel intense sensations in their legs. Below are some ways people have described what the sensations feel like, as reported by the Mayo Clinic:

Additional RLS Symptoms

Urge to move after resting

People with RLS may start to feel sensations after periods of rest or being seated for a longer amount of time.

Feel relief with movement

Another effect of this condition is that you feel relief through movement, including stretching, shaking your legs, or walking.

Worsens in the evening

RLS usually emerges or worsens at night.

Leg twitching at night

Leg twitching or kicking may also result from a condition linked to RLS known as Periodic Limb Movement Disorder. We will cover this in-depth further below.

How Often Do Symptoms Occur?

The frequency of symptoms[3] can vary from person to person. Moderate cases of RLS typically see symptoms occur about once or twice a week, while severe cases may cause symptoms to appear more than two times a week.


Sometimes RLS symptoms may go away for weeks or months at a time before reappearing. This typically happens in the early stages of developing this condition.

Section 2

Risk Factors for Restless Legs Syndrome

While more research needs to be done to determine what causes RLS to surface in the first place, experts say there are risk factors that may increase your chances.

Runs in the Family

Evidence suggests that RLS may be hereditary[4]. Researchers reported that certain genes present on chromosomes might be connected to restless legs syndrome, and this DNA could be passed down among family members. They also found that patients who experienced RLS at a younger age had a family history of the disorder.

Illustration of Tom Coming Home from Work and His Family Waiting for Him


According to the Mayo Clinic, the hormonal changes brought about due to pregnancy could cause RLS or intensify symptoms. In some cases, pregnant women may develop restless legs syndrome during their third trimester, and then the symptoms go away following delivery.


Get More Info: Restless Legs Syndrome in Pregnancy


Although people can get RLS at any age, your likelihood increases as you get older.

Illustration of an Elderly Man Sleeping in a Nursing Home


Both men and women can experience this condition, but it is more common in women.

Section 3

Is RLS Associated with Other Conditions?

Certain health conditions may be connected to Restless Legs Syndrome.

Periodic Limb Movement Disorder (PLMD)

Periodic Limb Movement Disorder – or PLMD[5] – is when a person experiences repetitive leg movements while asleep, disrupting their rest in the process. These movements typically occur in the lower half of the body in the hips, knees, ankle, or big toes. About 80 percent of individuals with Restless Legs Syndrome also experience PLMD.

Peripheral Neuropathy

Peripheral Neuropathy is when nerves in your hands and feet are damaged due to long-term conditions like alcoholism or diabetes. Peripheral Neuropathy may also be heredity. A 2008 study found that RLS was more common among people with hereditary neuropathy[6] than those who developed it.

Low Iron

Whether brought on by anemia or not, an iron deficiency may cause or exacerbate Restless Legs Syndrome. According to Johns Hopkins Medicine, studies have shown a correlation between low iron concentration in the substantia nigra area of the brain and severe RLS symptoms. The substantia nigra is a region of the brain where dopamine-producing cells are located.

Kidney Failure

Kidney Failure may also be linked to RLS. This is because malfunctioning kidneys can result in an iron deficiency, possibly triggering restless legs.

illustration of a person having lower back pain

Spinal Cord Injuries

The Mayo Clinic reports that damage or injuries to the spinal cord have also been linked to RLS. They add that anyone who has had anesthesia put in their spinal cord, including a spinal block, is also at an increased risk of developing Restless Legs Syndrome.

Section 4

How to Stop Restless Legs

Because it may be difficult to pinpoint the source of restless legs, treatment is usually focused on alleviating symptoms.


Lifestyle Changes

Health experts with the National Institute of Neurological Disorders and Stroke suggest that implementing the following changes and routines to your lifestyle may reduce restless legs.

Illustration of a Nurse Massaging Elderly-Lady's Legs

Iron Supplements

Because iron deficiency is considered a possible link to RLS, iron supplements may be able to help. Iron supplements are available over the counter, but there are some potential side effects to be aware of, including an upset stomach or constipation. In the event iron levels don’t improve with supplements, a doctor may need to administer iron through an IV line.


Anti-Seizure Drugs

According to the National Institute of Neurological Disorders and Stroke, anti-seizure drugs are rising in popularity as a prescription treatment for RLS, adding that the Food and Drug Administration has approved a drug called gabapentin enacarbil to help treat moderate to severe restless legs.


Dopamine Medications

Drugs that increase dopamine are primarily used to treat Parkinson’s Disease, and they’ve also been shown to minimize the effects of RLS when taken at night. However, experts warn that long-term use of dopamine medications may cause restless legs to worsen over time. They add that patients may also develop impulsive or obsessive behaviors.

Illustration of a Sleeping Pill Addicted Woman


Low doses of opioid medications have also been shown to manage restless legs syndrome. However, there are risks to taking opioids, including constipation, dizziness, nausea, worsening sleep apnea, and addiction.



Certain benzodiazepines are prescribed to alleviate anxiety, muscle spasms, and insomnia. In some cases, they may make sleep apnea symptoms worse and are not recommended for those with a sleep apnea disorder. Benzodiazepines may also lead to daytime fatigue, inability to focus, and less energy. 


These are typically considered a “last-line” treatment.

Section 5

Does RLS lead to Parkinson’s Disease?

For folks who have persistent RLS, they may be concerned that this condition is an early warning sign of Parkinson’s Disease.


The American Parkinson Disease Association reports that the majority of people with RLS do not develop Parkinson’s Disease[7]. They add that while some studies have shown RLS creates an increased risk of PD, other studies have not shown this result. Because the studies have produced inconsistent results, there is no conclusive evidence that experiencing Restless Legs Syndrome means that a person is at a higher risk for developing Parkinson’s Disease.

[1] “Restless Legs Syndrome”, Mayo Clinic, January 21, 2020.

[2] “Neurology and Neurosurgery”, Johns Hopkins Medicine

[3] “Restless Legs Syndrome Fact Sheet”, National Institute of Neurological Disorders and Stroke

[4] V. Dhawan, M. Ali, K.R Chaudhuri, Genetic aspects of restless legs syndrome”, National Center for Biotechnology Information

[5] “Periodic Limb Movement Disorder (PLMD) in Adults”, Cleveland Clinic, July 21, 2012.

[6] Erin Hattan, Colin Chalk, Ronald B. Postuma, Is there a higher risk of restless legs syndrome in peripheral neuropathy?”, Neurology, 2008.

[7] Dr. Rebecca Gilbert, “Restless Leg Syndrome and Parkinson’s Disease”, American Parkinson Disease Association, June 17, 2020.

 Dr Alex Dimitriu M.D.<br> <span class="job-title">Board-certified Psychiatrist, Founder of Menlo Park Psychiatry and Sleep Medicine</span>
Dr Alex Dimitriu M.D.
Board-certified Psychiatrist, Founder of Menlo Park Psychiatry and Sleep Medicine

Dr. Alex Dimitriu brings a deep respect for science and spirituality into his work. He is board-certified in psychiatry and sleep medicine and specializes in the complex interplay between the mind and body.

Using neuroscience and pharmacology to attain the most efficient and holistic solutions, he helps his patients achieve highly restorative sleep and optimal daytime performance.

Alex has been nationally recognized by The New York Times, Psychology Today, and NBC News. He has brought remarkable outcomes to the most challenging of cases through the optimization of wakefulness and sleep.

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